Dr. Walker's life long vision is to better understand the biological mechanism of aging. Through such understanding, clinical interventions that reduce intrinsic disease, improve quality of live and promote longevity may be developed. Walker's working hypothesis in pursuit of this vision is that development and senescence are distinct parts of a continuum of physical and functional change, initiated at conception and persisting until death. Since such complex reorganization must be carefully orchestrated to maintain homeostasis, he feels that strict genetic control of developmental transformation evolved to ensure survival until reproductive competence is achieved. At that point, species survival is guaranteed so that selective pressures to sustain individual life are lost. As a result, the genes that initiated dynamic transformation at conception are not silenced, eventually causing disorder and chaos within every organism. Dr. Walker's vision is to identify the gene(s) responsible for orchestrating internal reorganization and to modulate or terminate their expression after maturity is reached. Consistent with this vision, Walker has been working with the family of Brooke Greenberg a girl who seemingly has suffered a genetic mutation that significantly slowed and disorganized her development. He is hopeful that this research will eventually be fruitful, making healthy and vital life extension a reality for future generations. In the interim, he is working to develop clinical interventions that oppose the consequences of aging, reduce risk for age-related diseases and extend quality of life to the fullest extent possible.